Cyclic thrombocytopenia of apparent autoimmune etiology
نویسندگان
چکیده
منابع مشابه
Cyclic thrombocytopenia of apparent autoimmune etiology.
Serial studies were performed in two patients with cyclic thrombocytopenia to investigate the pathogenesis of this disorder. Mean life span of autologous platelets when platelet levels were declining was subnormal (2.4 and 0.8 days), and megakaryocytes were abundant in the bone marrow during thrombocytopenia. Megakaryocyte colony-stimulating activity could not be detected in the serum of either...
متن کاملCyclic thrombocytopenia: a thrombopoietin deficiency?
Severe cyclic thrombocytopenia is reported in a young woman. This rare phenomenon is of considerable theoretical interest in relation to platelet kinetics. In this patient platelet and fibrinogen survival times exclude the possibility of excessive peripheral platelet destruction. Serial plasma thrombopoietin levels suggest that a deficiency of this protein may be the underlying factor. As a res...
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Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...
متن کاملSpecificity of autoantibodies in autoimmune thrombocytopenia.
In 42 patients with autoimmune thrombocytopenia (AITP) and a positive direct platelet suspension immunofluorescence test (PSIFT), the antigenic specificity of the autoantibodies was studied. Because the autoantibodies were often not detectable in the serum and additional HLA antibodies may disturb the reaction pattern with the platelet panel, we used eluates prepared from the patients' platelet...
متن کاملMaternal autoimmune thrombocytopenia and the newborn.
That a humoral factor was the causative agent in idiopathic thrombocytopenic purpura was suggested nearly 30 years ago after the observation that mothers with the disease often give birth to children who develop transient thrombocytopenia.1 Maternal platelet autoantibodies were presumed to pass into the fetal circulation. With present techniques2 3 platelet autoantibodies are detectable in most...
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ژورنال
عنوان ژورنال: Blood
سال: 1989
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v73.6.1561.1561